Asymmetric allylation of carbonyl compounds Ring forming reactions, Baldwin rules cyclopentannulations with specific application to triquinanes. Addition of organometallinc reagents to imines, Asymmetric acetate/ propionate aldol reaction. Organic synthesis and total synthesis of complex natural products: Advances in C-C bond forming reactions Olefination reactions Olefin metathesis including alkyne metathesis Synthesis of alkynes Asymmetric addition of Grignard reagents, organozinc and lithium reagents to carbonyl compounds Directed lithiation, chiral lithium reagents alkylation of carbonyl compounds including asymmetric alkylation. Biochemistry 2nd Edition John Wiley Cysons NY, 1995. Important developments in current literature. Enzymes: mechanisms of selected enzymes, enzyme inhibitors. Peptidomimetics, isosteres, folding peptides. Protein solubility, pKa, protein aggregates, isofolding, unfolded proteins, membrane proteins. Protein architecture, protein-protein interactions, protein stability. Non-covalent interactions, dynamism in peptides, molecular recognition, Ramachandran plot, Foldamers. Pre-requisites: Successful completion of UC201 and 205 for UGĪmino acids, peptide synthesis, geometry and oligopeptide conformations. and Richardson K.S., Mechanism and Theory in Organic Chemistry, 3rd ed, Addison-Wesley-Longman, 1998. Carey F.A., and Sundberg R.J., Advanced Organic Chemistry, Part A. B., March J., March’s Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 6th ed.
#FOURTH EDITION MODERN PHYSICAL ORGANIC CHEMISTRY FREE#
Electronic effects in organic compounds, aromaticity, frontier orbital theory, steric effects organic transformations and molecular rearrangements reactive intermediates, classical and nonclassical carbocations, carbanions, free radicals, carbenes, nitrenes, arynes, radical ions, diradicals, concerted reactions, Woodward-Hoffman rules.Īnslyn, E.V., and Dougherty, D.A., Modern Physical Organic Chemistry, University Science Books, 2006. Methods of deducing organic reaction mechanisms, Hammond postulate, Curtin-Hammett principle, linear free energy relationships Hammett equation kinetic isotope effects. Stereochemistry and conformational analysis.